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US 2014/0004562 A1Published application
Reversibly water-soluble nanocrystals
AssigneeEast China University of Science and Technology
InventorsXinhua Zhong, Lu Liu
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AssigneeEast China University of Science and Technology
InventorsXinhua Zhong, Lu Liu
Estimating the term…
A general, facile, and reversible nanocrystal (NCs) phase transfer protocol via ligand exchange using nucleotides and/or nucleosides is provided to generate reversibly water-soluble nanocrystals. This phase transfer strategy can be employed on a wide variety of chemically synthesized nanostructured materials including semiconductors, metal oxides and noble metals with different sizes and shapes. The nucleotide/nucleoside-capped nanocrystals can disperse homogeneously in aqueous or alcohol media retaining, for example, high photoluminescence quantum yields. The disclosed water-soluble nanocrystals have excellent colloidal and photoluminescent stability independent on the pH and ionic strength, minimal hydrodynamic size, and are stable in cells and suitable for in vitro cell labeling, cell tracking, and other bioimaging applications.
A reversibly water-soluble nanocrystal comprising a core nanocrystal capped by a plurality of nucleotides, a plurality of nucleosides or a combination thereof.
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The reversibly water-soluble nanocrystal of claim, further characterized in that the conversion between water-solubility and water-insolubility may be carried out for at least ten cycles without significantly altering the performance characteristics of the nanocrystal.
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A method for producing reversibly water-soluble nanocrystals, the method comprising the steps of:
A method for reversibly transferring nanocrystals between a hydrophobic solution and a hydrophilic solution, the method comprising:
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A composition comprising a biological reagent coupled to a reversibly water-soluble nanocrystal comprising a core nanocrystal capped by a plurality of nucleotides, a plurality of nucleosides, or a combination thereof.
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A method for labeling a biological cell or molecular component of such cell, the method comprising the step of:
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A biological cell or molecular component of such cell labeled with a composition comprising a biological reagent coupled to a reversibly water-soluble nanocrystal comprising a core nanocrystal capped by a plurality of nucleotides, a plurality of nucleosides, or a combination thereof.
Dependencies are inferred from the claim text.