Method for Enzymatic Treatment of Tissue Products
AssigneeLifeCell Corporation
InventorsYi Chen, Hui Xu, Li Ting Huang, Wenquan Sun
Life of this patent
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Abstract
Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.
Claims17
A method for treating a tissue matrix, comprising:
- selecting at least one collagen-containing tissue matrix;
- contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme;
- and
- performing an assay to determine if contacting the at least one collagen-containing tissue matrix with the at least one proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix when the tissue matrix is implanted in a human body.
Dependencies are inferred from the claim text.