US 2014/0004538 A1Published application

Method for diagnosing invasive candida infections

AssigneesBio-Rad Innovations, Centre Hospitalier Universitaire De Lille, Universite Lille 2 Droit Et Sante

InventorsSebastien DAMIENS, Chantal FRADIN, Daniel POULAIN, Boualem SENDID, Marc Charles Victor TABOURET

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Abstract

The present invention concerns an in vitro method for diagnosing invasive candidiasis (IC) in a subject which comprises detecting the presence of a Candida glycan and detecting the presence of antibody directed against a protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hyphal wall protein (Hwp1), and mannoprotein 65 (Mp65) in a blood, plasma or serum sample of the subject. The invention also relates to a method of determining a suitable treatment regimen for a patient and to a kit for implanting the methods described herein.

Claims15

Dependent claims

An in vitro method for diagnosing invasive candidiasis (IC) in a subject, said method comprising the steps consisting of:

a) detecting the presence of a Candida glycan in a blood, plasma or serum sample of the subject;
b) detecting the presence of antibody directed against a Candida protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hyphal wall protein (Hwp1), and mannoprotein 65 (Mp65) in a blood or plasma sample of the subject;
and
c) wherein the presence of said Candida glycan and/or of said antibody directed against a protein selected from the group consisting of Fba1, Eno1, Hsp90, Hwp1, and Mp65, is indicative of IC.

1 more element

Dependencies are inferred from the claim text.