Marker for diagnosing diabetic retinopathy and use thereof
AssigneesSnu R&Db Foundation, LG Electronics Inc.
InventorsYunhee KU, Yongju YANG, Youngsoo KIM, Jonghwa JIN, Kyunggon KIM, Moosub KIM, Seungyeon SONG
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Abstract
The present invention relates to a marker which can be used to diagnose a diabetic retinopathy patient and determine the progression of diabetic retinopathy, a composition for diagnosing diabetic retinopathy, which comprises an agent for measuring the level of a gene or protein associated with the marker, and the use thereof.
Claims12
At least one marker for diabetic retinopathy, the marker selected from a group consisting of C7 (complement component C7), ITIH2 (inter-alpha-trypsin inhibitor heavy chain H2) and C5 (complement C5).
A composition for diagnosing diabetic retinopathy, comprising an agent for measuring the mRNA or protein level of at least one gene selected from the group consisting of C7 (complement component C7), ITIH2 (inter-alpha-trypsin inhibitor heavy chain H2) and C5 (complement C5).
A method for providing information for diagnosis of diabetic retinopathy, the method comprising the steps of:
- measuring the expression level of at least one gene or its protein, selected from the group consisting of C7 (complement component C7), ITIH2 (inter-alpha-trypsin inhibitor heavy chain H2) and C5 (complement C5), in a biological sample;
- and comparing the expression level of the gene or its protein with that in a normal control sample.
Dependencies are inferred from the claim text.