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US 2014/0004512 A1Published application
Quality determination of stem cells
AssigneesPeter Wernet, Foued Ghanjati, Simeon Santourlidis, Nicole Groth
InventorSimeon Santourlidis
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Abstract
The invention relates to a method for determining the quality of a pluripotent stem cell, comprising the following steps: measuring the DNA methylation of at least one CpG in a CpG island in at least two genes of the pluripotent stem cell, comparing it to the DNA methylation of the at least one CpG in a CpG island in the at least two genes of at least one reference cell, wherein the genes are located on different chromosomes and belong to the gene family of olfactory receptor genes.
Claims13
A method for determining the quality of a pluripotent stem cell, comprising the steps of:
- measuring the DNA methylation of at least one CpG in a CpG island in at least three genes of the pluripotent stem cell;
- comparing with the DNA methylation of said at least one CpG in a CpG island in said at least three genes of at least one reference cell;
- wherein said genes are located on different chromosomes and belong to the gene family of olfactory receptor genes.
Dependencies are inferred from the claim text.