Microbes with an improved ability to produce ornithine and method for producing ornithine using same
AssigneeCj Cheljedang Corporation
InventorsHyang Choi, Kyoung Min Lee, Min Sun Kang, Sung Hoo Jhon, Hye Won Um, Su Jin Choi, Han Won Lee, Soo An Shin
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Abstract
The present invention relates to a microorganism having an improved ornithine-producing ability, in which the biosynthetic pathway of arginine form ornithine is blocked, the intracellular glutamate level is increased, and the biosynthetic pathway of ornithine from glutamate is enhanced, and a method for producing ornithine using the microorganism.
Claims11
A microorganism having an improved ornithine-producing ability, wherein the activities of ornithine carbamoyltransferase and a protein involved in glutamate export (NCgl1221) are modified to be attenuated, compared to their endogenous activities.
A method for producing ornithine, comprising the steps of:
- (i) culturing a microorganism having an improved ornithine-producing ability, wherein the activities of ornithine carbamoyltransferase and a protein involved in glutamate export (NCgl1221) are modified to be attenuated;
- and
- (ii) recovering ornithine from the cultured microorganism or the culture.
Dependencies are inferred from the claim text.