Preparation of brushite and octacalcium phosphate granules
OwnerAhmet Cuneyt Tasinventor
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Abstract
Brushite (DCPD, dicalcium phosphate dihydrate, CaHPO4-2HH2O) and octacaicium phosphate (OCP, Ca8(HPO4)2(PO4)4-5H2O) granules in the millimetre size range were prepared by using calcium carbonate granules of marble-origin as the starting material. The method of the invention comprised of soaking the marble granules in aqueous solutions containing phosphate and/or calcium ions at temperatures between 20° and 75° C. The load-bearing DCPD and OCP granules of this invention are useful in maxillofacial and orthopedic void/bone defect filiing and grafting applications.
Claims23
A method of preparing granules based on octacalcium phosphate (Ca8(HPO4)2(PO4)4.5H2O) for surgical use characterized in that the method comprises the steps of:
- (a) preparing, at room temperature, an aqueous solution by using distilled water containing Na+, K+, Mg2+, Cl−, HCO3−, NH4+, H2PO4−, Ca2+ and/or HPO42− ions,
- (b) adding brushite (dicalcium phosphate dihydrate. CaHPO4.2H2O) granules into the solution,
- (c) soaking the granules in the solution for 24 to 168 hours between 37° and 75° C. without stirring,
- (d) separating the octacalciurn phosphate granules from the solution by filtration,
- (e) washing the octacalcium phosphate granules with water,
- (f) drying the octacalcium phosphate granules at 37° C. from 20 to 36 hours.
Dependencies are inferred from the claim text.