Methods for the regulation of the prostaglandin f synthase (pgfs) activity of akr1b1 and uses thereof
AssigneeUniversite Laval
InventorsMichael Fortier, Pierre Chapdelaine, Eva Bresson, Éric Madore
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Abstract
AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH2 into PGF2α. AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF2α are also provided.
Claims6
A method for treating or preventing ischemia in a subject, said method comprising the step of administering an inhibitor of PGF2α synthase activity of AKR1B1 (EC 1.1.1.21) to said subject.
Dependencies are inferred from the claim text.