Antifungal nail coat and method of use
AssigneesNexmed Holdings, Inc., Apricus Biosciences, Inc
InventorsStanley W. Kepka, Y Joseph Mo, Hang-Yong Wang, Mingqi Lu, William R. Pfister
Life of this patent
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Abstract
Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.
Claims9
1-22. (canceled)
A method for ameliorating or preventing fungal infection of a toenail or fingernail comprising contacting a fungally susceptible or infected nail and skin tissue adjacent thereto with a nail coat composition consisting essentially of, on a total composition weight basis:
- about 0.5 to about 10 weight percent terbinafine hydrochloride:
- about 0.1 to about 25 weight percent dodecyl-2-(N,N-dimethylamino) isopropionate hydrochloride:
- about 0.1 to about 10 weight perecent benzyl alcohol;
- about 0.1 to about 5 weight percent polyvinylpyrrolidone;
- and
- the remainder ethanol.
Dependencies are inferred from the claim text.