Supramolecular complexes of polyanionic polymers and spermidine in tissue maintenance and repair
AssigneeTixupharma
InventorCarlo Ghisalberti
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Abstract
Supramolecular complexes are formed by polyanionic polymers and spermidine having a ratio of anionic equivalents raging from 101:1 to 107:1 eq/eq, more preferably from 102:1 to 104:1 eq/eq, whose components are linked by non-covalent, ionic interactions. The supramolecular complexes are exhibit high potency in eliciting fibroblast proliferation. Disclosed are medicinal/cosmetic compositions containing the supramolecular complexes for the trophism, maintenance, regeneration, and repair of connective tissues and mucosae in damaged or senescent conditions.
Claims23
A supramolecular complex formed by at least a polyanionic polymer and spermidine with a ratio of anionic equivalents and cationic equivalents from 10:1 to 107:1 eq/eq, where the components of said supramolecular complex are intimately admixed, without any covalent bond between them.
A composition according to claim 21 wherein said damaged or senescent tissue is selected from the group consisting of vaginal mucosa, urethral mucosa, eyes, ear, throat and nose mucosae, oral mucosa, gingiva and periodontum, gastrointestinal mucosae, senescent skin and adnexa, dermal and hypodermal layers, synovial fluid and joint tissues, and alveolar mucosa.
A composition according to claim 21 comprising a supramolecular complex of polyanionic polymer(s) and spermidine ≧10:1 eq/eq ratio in amount from 1 to 0.001 μmol of equivalent spermidine per dose by topical or intramucosal administration.
A composition according to claim 21 comprising a supramolecular complex of polyanionic polymer(s) and spermidine ≧10:1 eq/eq ratio in amount from 1 to 0.001 μmol of equivalent spermidine per sterile dose by instillation or local injection.
Dependencies are inferred from the claim text.