Method and System for Accurate Construction Of Long Range Haplotype
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsNicholas Johnson, Wing H. Wong, Hua Tang
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AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsNicholas Johnson, Wing H. Wong, Hua Tang
Estimating the term…
In an embodiment of the present invention, a modified version of the PHASE model is implemented that is substantially more accurate than the FastPHASE model. Modifications in an embodiment of the present invention include using a parameterization EM algorithm similar to that of the FastPHASE model, and to perform optimization on haplotypes rather than MCMC sampling. In an embodiment, the imputed haplotypes themselves are used as hidden states in the HMM because this is believed to be important for the PHASE model's accuracy. This increase in accuracy becomes more pronounced with increasing sample size. This difference is attributed to the PHASE model's likelihood which produces long, shared haplotypes between pairs of individuals.
A computerized method for interpreting genetic data, comprising:
A computer-readable medium including instructions that, when executed by a processing unit, cause the processing unit to interpret genetic data, by performing the steps of:
A computing device comprising:
Dependencies are inferred from the claim text.