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US 2013/0296932 A1Published application
Surface induced ring-opening polymerization and medical devices formed therefrom
AssigneeCovidien LP
InventorsNadya D. Belcheva, Norman Aminuddin
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Abstract
The present disclosure relates to coated biodegradable materials having a reduced amount of residual catalysts and methods thereof.
Claims20
A biodegradable polymeric material comprising:
- a substrate containing a reduced amount of a residual catalyst;
- and
- a biodegradable coating positioned on at least a portion of the substrate, wherein the biodegradable coating is grafted via interpenetrating mechanisms through a surface of the substrate.
A method of inducing ring-opening polymerization of a cyclic ester monomer on a surface of a medical device comprising:
- providing a closed container which includes a cyclic ester monomer and a biodegradable polymeric medical device including a residual catalyst;
- and
- heating the closed container to at least a glass transition temperature of the biodegradable polymeric medical device and below the crystallization temperature of the biodegradable polymeric medical device to induce ring-opening polymerization of the cyclic ester monomer with the residual catalyst.
A method of grafting a biodegradable coating onto a surface of a biodegradable polymeric material comprising:
- providing a container which includes at least one monomer capable of polymerizing via cationic ring-opening polymerization and a pellet of a biodegradable polymeric material containing a residual catalyst;
- and
- placing the container with the pellet of biodegradable polymeric material in an oven for a period of time, wherein the oven is heated above the glass transition temperature and below the crystallization temperature of the biodegradable polymeric material;
- polymerizing the monomer with the residual catalyst to form a coated pellet;
- and,
- processing the coated pellet to form an implantable medical device.
3 more elements
Dependencies are inferred from the claim text.