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US 2013/0296607 A1Published application
Acetamide Stereoisomer
AssigneeSunovion Pharmaceuticals Inc.
InventorsCraig R. Abolin, H. Scott Wilkinson, Paul McGlynn, William K. McVicar
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Abstract
The compound of formula (I) is a water-stable, long acting β2-selective adrenoceptor agonist useful as a bronchodilator in the treatment of bronchoconstriction associated with reversible obstructive airways diseases and the like. Processes for making the compound of formula (I), as well as related intermediates, are disclosed.
Claims4
A process for the preparation of
- which comprises reacting a compound of general formula (II)
- in which P1 represents a hydrogen atom or a hydroxyl protecting group, with a compound of general formula (III)
- in which P2 represents a hydrogen atom or a trialkylsilyl and P3 represents a benzylic amine protecting group, to afford a compound of general formula (IV)
- or a salt thereof, followed by removing any protecting groups P1, P2 and P3 and, if desired, forming a pharmaceutically acceptable acid addition salt.
1 more element
A process for the preparation of
- which comprises
- a) reacting a compound of general formula (VII)
- wherein Bn represents benzyl,
- with boron tribromide to form a compound of general formula (VIII)
- b) reacting said compound of general formula (VIII) with trialkylsilyl halide to form a compound of general formula (III)
- in which P2 represents a trialkylsilyl;
- c) reacting said compound of general formula (III) with a compound of general formula (II)
- in which P1 represents a hydrogen atom or a hydroxyl protecting group, to afford a compound of general formula (IV)
- or a salt thereof;
- d) reducing with a source of hydrogen in the presence of a noble metal catalyst and treating with fluoride ion;
- and
- e) if desired, forming a pharmaceutically acceptable acid addition salt.
9 more elements
Dependencies are inferred from the claim text.