Block copolymers for stable micelles

A triblock copolymer of formula II:

• wherein:
• n is 20-500;
• m is 0, 1, or 2;
• x is 3 to 50;
• y is 5 to 100;
• Ry is selected from one or more natural or unnatural amino acid side chain groups such that the overall block is hydrophobic;
• R1 is —Z(CH2CH2Y)p(CH2)tR3, wherein:
• Z is —O—, —NH—, —S—, —C≡C—, or —CH2—;
• each Y is independently —O— or —S—;
• p is 0-10;
• t is 0-10;
• and
• R3 is hydrogen, —N3, —CN, —NH2, —CH3,
• a strained cyclooctyne moiety, a mono-protected amine, a di-protected amine, an optionally protected aldehyde, an optionally protected hydroxyl, an optionally protected carboxylic acid, an optionally protected thiol, or an optionally substituted group selected from aliphatic, a 5-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur.