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US 2013/0296460 A1Published application
In situ bonds
AssigneePromethean Surgical Devices, LLC
InventorMichael T. Milbocker
Life of this patent
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Abstract
A biocompatible tissue-bonding adhesive composition having a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N−1)% of the solution having free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.
Claims26
-39. (canceled)
A biocompatible composition comprising
- a cyanate-terminated hydrophilic prepolymer comprising:
- a copolymer comprising polyether monomers and from 10% to 30% of propylene oxide monomers;
- from 23 to 39 wt. % of at least one polyisocyanate selected from the group consisting of 2,4-touluene diisocyanate, 2,6-toluene diisoscyanate, and isophorone diisocyanate;
- and
- from 1 to 5 wt. % of trimethylolpopane;
- wherein the prepolymer is a liquid, water-soluble, and comprises from 1.5 to 5% free polyisocyanate content.
3 more elements
A hydrated, biocompatible composition comprising:
- at least one isocyanate terminated hydrophilic prepolymer derived from reaction of an organic polyisocyanate, at least one oxyethylene-based copolymer, and a triol;
- and
- an aqueous solution.
Dependencies are inferred from the claim text.