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US 2013/0296441 A1Published application
Anti-Obesity Properties of Pterostilbene
OwnerAgnes Rimando, Maria del Puy Portilloinventors
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OwnerAgnes Rimando, Maria del Puy Portilloinventors
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We have determined that pterostilbene demonstrates anti-obesity properties. Rats were fed a commercial obesogenic diet supplemented or not with pterostilbene: PT15 (low dose: 15 mg/kg body weight/d) or PT30 (high dose: 30 mg/kg body weight/d) for 6 weeks. Pterostilbene significantly reduced total adipose tissue mass (15.1% in the PT15 group; 22.9% in the PT30 group) without changes in food intake. The activities of lipogenic enzymes were reduced in white adipose tissue and liver. Activities of enzymes involved in liver fatty acid oxidation were significantly increased in the PT30 group. Low dose pterostilbene can reduce body fat by reducing lipogenesis in adipose tissue. At the high dose, two mechanisms contribute to reduction in body fat: (1) decrease in adipose tissue and liver lipogenesis, and (2) an increase in liver fatty acid oxidation.
A method for treating or alleviating obesity in an individual comprising administering to an individual in need thereof a therapeutically effective amount of a pharmaceutical or nutraceutical composition consisting essentially of isolated or chemically-synthesized pterostilbene, its pharmaceutically or nutraceutically acceptable salts or isomers thereof and a pharmaceutically or nutraceutically acceptable carrier, wherein the composition is effective to treat obesity in the individual.
A method of decreasing the total adipose tissue mass in an individual comprising administering to an individual in need thereof a therapeutically effective amount of a pharmaceutical or nutraceutical composition consisting essentially of isolated or chemically-synthesized pterostilbene, its pharmaceutically or nutraceutically acceptable salts or isomers thereof and a pharmaceutically or nutraceutically acceptable carrier, wherein the composition is effective to decrease the total adipose tissue mass in the individual.
A method of reducing adipose depots in anatomical locations in an individual comprising administering to an individual in need thereof a therapeutically effective amount of a pharmaceutical or nutraceutical composition consisting essentially of isolated or chemically-synthesized pterostilbene, its pharmaceutically or nutraceutically acceptable salts or isomers thereof and a pharmaceutically or nutraceutically acceptable carrier, wherein the composition is effective to reduce adipose depots in anatomical locations in the individual.
A method of inhibiting lipogenesis in an individual comprising administering to an individual in need thereof a therapeutically effective amount of a pharmaceutical or nutraceutical composition consisting essentially of isolated or chemically-synthesized pterostilbene, its pharmaceutically or nutraceutically acceptable salts or isomers thereof and a pharmaceutically or nutraceutically acceptable carrier, wherein the composition is effective to inhibit lipogenesis in the individual.
A method of increasing fatty acid oxidation in the liver of an individual comprising administering to an individual in need thereof a therapeutically effective amount of a pharmaceutical or nutraceutical composition consisting essentially of isolated or chemically-synthesized pterostilbene, its pharmaceutically or nutraceutically acceptable salts or isomers thereof and a pharmaceutically or nutraceutically acceptable carrier, wherein the composition is effective to increase fatty acid oxidation in the liver of the individual.
Dependencies are inferred from the claim text.