Artemisinin-Like Derivatives with Cytotoxic and Anti-Angiogenic Properties
AssigneeDafra Pharma N.V.
InventorFrans Herwig Jansen
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Abstract
The present invention relates to novel artemisinin-like derivates, and especially dihydroartemisinin derivates and pharmaceutical compositions comprising the present compounds. The present invention further relates to the use of the present compounds for the treatment of cancer, especially by oral administration. Especially, the present invention relates to dihydroartemisinin compounds (DHA) substituted by, through an ester linkage by a linear or branched C1 to C6 alkyl optionally substituted by one or more halogens. Especially preferred substituents are acetate, propionate, isopropionate, butyrate and isobutyrate.
Claims12
Compound comprising an artemisinin derivative according to the general formula:
- wherein R is a linear or branched C1 to C6 alkyl.
8-10. (canceled)
Dependencies are inferred from the claim text.