Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions
AssigneeAllergan, Inc.
InventorsMohammed I. Dibas, Daniel W. Gil, John E. Donello, Ken Chow, Liming Wang, Michael E. Garst
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Abstract
The present invention relates to method for treating skin diseases and skin conditions in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising ester pro-drugs of [3-(1-(1H-imidazol-4-yl) ethyl)-2-methylphenyl]methanol, or enantiomers thereof, pharmaceutical compositions containing them and their use as pharmaceuticals.
Claims11
A pharmaceutical composition for treating rosacea, administered to a subject in need of such treatment, comprising a compound having a structure of Formula II
- wherein:
- R1 is H or optionally substituted C1-3 alkyl;
- R2 is H or optionally substituted C1-3 alkyl;
- R3 is H, optionally substituted C1-10 alkyl, optionally substituted heterocycle or optionally substituted aryl;
- and
- R is optionally substituted C1-10 alkyl, optionally substituted heterocycle or optionally substituted aryl;
- or
- a pharmaceutically acceptable salt thereof;
- and
- pharmaceutically acceptable carriers, preservatives, auxiliary agents, stabilizing agents, thickening agents, coloring agents and perfumes.
A pharmaceutical composition for treating rosacea for topical dermatological, comprising a compound having a structure of Formula II
- wherein:
- R1 is H or optionally substituted C1-3 alkyl;
- R2 is H or optionally substituted C1-3 alkyl;
- R3 is H, optionally substituted C1-10 alkyl, optionally substituted heterocycle or optionally substituted aryl;
- and
- R is optionally substituted C1-10 alkyl, optionally substituted heterocycle or optionally substituted aryl;
- or
- a pharmaceutically acceptable salt thereof;
- and
- formulated as suspension, gel, solution, lotion, cream, ointment, foams, emulsions, microemulsions, milks, serums, aerosols, sprays, dispersions, microcapsules, vesicles, microparticles, nanoparticles, wet cloths, soaps, cleansing bars, dry cloths, facial cloths.
Dependencies are inferred from the claim text.