Novel Ureas for the Treatment and Prevention of Cancer

A compound of Formula (I) or a pharmaceutically acceptable salt, prodrug, metabolite, or isolated stereoisomer thereof,

• wherein:
• Y is O, S, S(O), S(O)2, or NR4;
• L is —NR4—X—, —X—NR4—, —NR4—X—NR4—, —NR4—, O, S;
• X is —C(O)—, —C(S)—, —S(O)2—, or
• Z and Z′ are each independently N or CRa;
• each Ra independently hydrogen, halo, C1-6alkyl optionally substituted with one of more halo;
• R1 and R2 are each independently alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, or halo;
• R3 is hydrogen, halo, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkenyl, carbonitrile, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, amino, substituted amino, acyl, acylamino, alkoxy, substituted alkoxy, carboxyl, carboxyl ester, substituted C1-6alkylsulfonyl, aminosulfonyl, or aminocarbonyl;
• each R4 is independently hydrogen or alkyl:
• Ring A is aryl or heteroaryl;
• and
• m and n are each independently 0, 1, 2, or 3.