Compositions and methods for alleviating depression or improving cognition
AssigneeClera Inc.
InventorsPhilip Seeman, Philip M. Toleikis
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Abstract
This application describes compositions of receptor inhibitors, including antipsychotic agents, for example haloperidol, and methods of use for alleviating clinical depression, improving cognition and/or treating other syndromes, conditions or diseases for which anti-depressant agents are prescribed. Furthermore, this application describes compositions and methods to induce supersensitivity in dopamine D2 and other receptors involved in depression and/or cognition as a means of alleviating clinical depression or improving cognition.
Claims15
A method of treating depression, of improving cognition and/or treating other syndromes, conditions or diseases for which anti-depressant agents are prescribed, comprising administering, to a subject in need thereof, an amount of a receptor inhibitor that is effective to elevate amounts of the high affinity state of the receptor, inducing receptor supersensitivity, wherein the receptor state is associated with depression, cognition and/or other conditions, syndromes or diseases for which antidepressants are prescribed.
The method according to claim I, wherein the receptor is the dopamine D2 receptor.
Dependencies are inferred from the claim text.