Glucagon receptor modulators

A compound of Formula I

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is a 5 membered heteroaryl group attached through either a carbon or nitrogen atom and which is optionally fused to a (C4-C7)cycloalkyl, phenyl or 6 membered heteroaryl;
• wherein the optionally fused 5 membered heteroaryl is optionally substituted with one to four substituents each independently selected from halo, —S(O)2—(C1-C3)alkyl, —S—(C1-C3)alkyl, hydroxy, —C(O)NRaRb, (C3-C5)cycloalkyl, cyano, phenyl which is optionally substituted with one to three halo, cyano, (C1-C3)alkyl or (C1-C3)alkoxy, 6 membered heteroaryl which is optionally substituted with one to three halo, cyano, (C1-C3)alkyl or (C1-C3)alkoxy, (C1-C6)alkyl optionally substituted with one to three fluoro, or (C1-C6)alkoxy optionally substituted with one to three fluoro;
• Ra and Rb are each independently H or (C1-C3)alkyl;
• R2 is H or methyl;
• R3 is tetrazolyl, —CH2-tetrazolyl, —(CH2)2SO3H or —(CH2)2CO2H, —CH2CHFCO2H or —CH2CHOHCO2H;
• A1, A2, A3 and A4 are each independently CR4 or N, with the proviso that no more than two of A1, A2, A3 and A4 are N;
• R4 at each occurrence is independently H, halo, cyano, (C1-C3)alkyl optionally substituted with one to three fluoro, or (C1-C3)alkoxy optionally substituted with one to three fluoro;
• L is —X—CH(R5)— or —CH(R5)—X—;
• X is CH2, O or NH;
• R5 is (C1-C6)alkyl which is optionally substituted with one to three fluoro, hydroxy or methoxy;
• (C3-C7)cycloalkyl which is optionally substituted with one to two (C1-C3)alkyl which are optionally substituted with one to three fluoro and wherein one to two carbons of the (C3-C7)cycloalkyl can be replaced with a NH, N(C1-C3)alkyl. O or S;
• or (C3-C7)cycloalkyl-(C1-C6)alkyl wherein the (C3-C7)cycloalkyl group of said (C3-C7)cycloakyl-(C1-C6)alkyl is optionally substituted with one to two (C1-C3)alkyl which are optionally substituted with one to three fluoro;
• B1, B2, B3 and B4 are each independently CR6 or N, with the proviso that no more than two of B1, B2, B3 and B4 are N;
• and
• R6 at each occurrence is independently H, halo, (C1-C3)alkyl optionally substituted with one to three fluoro, or (C1-C3)alkoxy optionally substituted with one to three fluoro.