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US 2013/0296339 A1Published application
Isoindolinone derivatives
AssigneeHoffmann-La Roche Inc.
InventorsSteven Joseph Berthel, Robert Francis Kester, Lucja Orzechowski
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Abstract
The present invention relates to compounds of the formula I, as well as pharmaceutically-acceptable salts thereof, pharmaceutical compositions containing said compounds and methods of using said compounds in the treatment or prophylaxis of diseases and disorders. The compounds and compositions disclosed herein are glucokinase activators useful for the treatment or prophylaxis of metabolic diseases and disorders, for example diabetes mellitus, including type II diabetes mellitus.
Claims7
A compound according to formula (I),
- wherein:
- R1 is CF3;
- R2 is selected from the group consisting of:
- isopropyl, cyclopentyl, and —CH2—S—CH3;
- R3 is
- R4 is selected from the group consisting of:
- H, Br, and —CH(OH)—CH2OH or a pharmaceutically-active salt of said compound.
4 more elements
Dependencies are inferred from the claim text.