Quinoline and Quinoxaline Derivatives as Kinase Inhibitors

A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof:

• wherein
• U represents —CF3, —CHF2 or —CH2F;
• Q represents oxygen, sulfur, N—R4 or a covalent bond;
• Z represents an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings, the heteroaryl moiety Z containing at least one nitrogen atom and being linked to the remainder of the molecule through a carbon atom;
• M represents aryl or heteroaryl, either of which groups may be optionally substituted by one or more substituents;
• W represents C—R5 or N;
• R1, R2 and R3 independently represent hydrogen, halogen, cyano, nitro, C1-6 alkyl, trifluoromethyl, C3-7 cycloalkyl(C1-6)alkyl, C3-7 heterocycloalkyl(C1-6)alkyl, aryl(C1-6)-alkyl, heteroaryl(C1-6)alkyl, hydroxy, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, amino, C1-6 alkylamino, di(C1-6)alkyl-amino, C2-6 alkylcarbonylamino, C2-6 alkoxycarbonylamino, C1-6 alkylsulfonylamino, formyl, C2-6 alkylcarbonyl, carboxy, C2-6 alkoxycarbonyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylaminocarbonyl, aminosulfonyl, C1-6 alkylaminosulfonyl or di(C1-6)alkylaminosulfonyl;
• R4 represents hydrogen or C1-6 alkyl;
• and
• R5 represents hydrogen, halogen, C1-6 alkyl or C1-6 alkoxy.