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US 2013/0296325 A1Published application
HIGH DRUG LOAD TABLET FORMULATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER
AssigneeBristol-Myers Squibb Company
InventorsAjit S. Narang, Sherif Ibrahim Farag Badawy, Ganeshkumar A. Subramanian, Keirnan Ryan LaMarche, Dilbir S. Bindra, Venkatramana M. Rao
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Abstract
The present invention is directed to a high drug load tablet formulation of [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester, and to methods of using the formulation in the treatment of cancer. The tablet is obtained by means of a wet granulation process.
Claims15
A high drug load tablet formulation of Compound Ia of the formula
- which comprises Compound Ia as the active pharmaceutical ingredient and one or more fillers, binders, disintegrants, glidants and/or lubricants.
A wet granulated tablet formulation of Compound Ia of the formula
- which comprises Compound Ia as the active pharmaceutical ingredient and one or more fillers, binders, disintegrants, glidants and/or lubricants.
Dependencies are inferred from the claim text.