Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
AssigneeThe Regents of the University of California
InventorsRanjan Dohil, John Bastian, Seema S. Aceves, Elaine Phillips, Malcolm Hill
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Abstract
Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
Claims28
A method of preventing or alleviating esophageal inflammation in an individual comprising orally administering to said individual a corticosteroid in association with at least one viscosity enhancing excipient, wherein upon oral administration, the corticosteroid is present in a medium with a viscosity of at least 2 cP at 25 degrees Celcius and a shear rate of about 13.2 sec−1.
An oral pharmaceutical composition comprising a therapeutically effective amount of a corticosteroid, and a liquid vehicle, wherein the pharmaceutical composition has a viscosity of greater than 2 cP at 25° C. and a shear rate of about 13.2 sec−1, and wherein the pharmaceutical composition is suitable for oral administration.
Dependencies are inferred from the claim text.