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US 2013/0296278 A1Published application
Diazeniumdiolate Derivatives
AssigneeMerck Sharp & Dohme Corp.
InventorsAmjad Ali, Michael Man-Chu Lo, Edward Metzger, Shrenik K. Shah, James Dellureficio
Life of this patent
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Abstract
A compound having the structure (I) useful for treating hypertension, pulmonary arterial hypertension, congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
Claims20
A compound of formula I:
- where M+ is a pharmaceutically acceptable cation;
- R1, R2 and R3 are independently —C1-6alkyl;
- and
- R4 is —C1-6alkyl, —CH2CH═CH2, aryl, C3-8carbocycle, heteroaryl, or heterocycle;
- wherein alkyl is unsubstituted or independently substituted at any carbon atom with —OH, aryl, C3-8carbocycle, heteroaryl, or heterocycle, and
- wherein, when R1, R2 and R3 are —CH3, R4 is not —CH3 or —CH2CH3.
3 more elements
A method for treating hypertension in a patient comprising administering to the patient a compound of formula I:
- where M+ is a pharmaceutically acceptable cation;
- R1, R2 and R3 are independently —C1-6alkyl;
- and
- R4 is —C1-6alkyl or —CH2CH═CH2;
- and
- wherein alkyl is unsubstituted or substituted with —OH or —C6H5.
3 more elements
A method of claim 11, wherein the compound is of formula la
Dependencies are inferred from the claim text.