Compstatin and analogs thereof for eye disorders
AssigneePotentia Pharmaceuticals, Inc.
InventorsPascal Deschatelets, Paul Olson, Cedric Francois
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Abstract
The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, choroidal neovascularization, and/or retinal neovascularization. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a second therapeutic agent. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a gel-forming material, e.g., soluble collagen, and methods of administering the compositions.
Claims22
A method of treating an eye disorder characterized by macular degeneration, choroidal neovascularization, retinal neovascularization, proliferative vitreoretinopathy, glaucoma, ocular inflammation, or any combination of these, comprising the step of:
- administering a composition comprising an effective amount of a compstatin analog to a subject at risk of or suffering from the eye disorder.
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A method of identifying compstatin mimetics for use in treatment of eye disorders characterized by macular degeneration, choroidal neovascularization, retinal neovascularization, ocular inflammation, or combinations thereof, the method comprising:
- providing one or more test compounds or molecular structures thereof;
- identifying a candidate compstatin mimetic by selecting one or more of the test compounds or structures thereof that binds to substantially the same region of human C3 as does compstatin;
- and
- determining C3-inhibitory activity of the candidate compstatin mimetic.
A method of identifying a compstatin mimetic that binds to C3 for use in treatment of eye disorders characterized by macular degeneration, choroidal neovascularization, retinal neovascularization, ocular inflammation, or combinations thereof, the method comprising comprising:
- providing a three-dimensional structure of compstatin or a compstatin analog bound to C3 or a portion thereof;
- computationally docking one or more molecular structures with the C3-binding site of compstatin or a compstatin analog in a three-dimensional structure of C3 or a portion thereof;
- and
- selecting one or more molecular structures that form substantially the same intermolecular contacts with the C3-binding site as compstatin or the compstatin analog, thereby identifying a candidate compstatin mimetic.
Dependencies are inferred from the claim text.