Prolinamiade derivatives as thrombin inhibitor, prepraration method and application thereof

A compound of formula (I), pharmaceutically acceptable salt and pharmaceutically acceptable prodrug thereof:

• wherein:
• A represents C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, —SO2R1, —SO3R1, —COR1, —CO2R1, —PO(OR1)2, —R2-cycloalkyl, —R2-heterocycloalkyl, —R2-aryl, —R2SO2R1, —R2SO3R1, —R2COR1, —R2CO2R1, or —R2PO(OR1)2;
• wherein:
• R1 represents H, C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, —R3-cycloalkyl, —R3-heterocycloalkyl, —R3-aryl, alkenyl or —NR4R5;
• R2 and R3 represent C1-6 alkyl;
• R4 and R5 represent independently H, C1-6 alkyl, cycloalkyl or heterocycloalkyl;
• B represents H;
• D represents
• E represents
• which are substituted or unsubstituted on the ring;
• wherein substituents on the ring are selected from carboxyl, halogen, alkyl, alkoxy, acyl, sulfonyl, sulfhydryl, alkylthio, cycloalkyl, heterocycloalkyl, amino, alkylamino, dialkylamino, cyano, ester group, trifluoromethyl or C1-4 alkyl carrying the above groups;
• F represents —NH—(CH2)m—R6;
• wherein:
• m represents 0-3;
• R6 represents unsubstituted
• wherein:
• X, Y and Z represent independently S, O or N;
• G represents
• wherein:
• n represents 0-3;
• p represents 1-8;
• R7 represents H or C1-6 alkyl.