Use Of Chloroquine To Treat Metabolic Syndrome
AssigneesWashington University, St. Jude Children's Research Hospital
InventorsMichael B. Kastan, Clay F. Semenkovich, Jochen Schneider
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AssigneesWashington University, St. Jude Children's Research Hospital
InventorsMichael B. Kastan, Clay F. Semenkovich, Jochen Schneider
Estimating the term…
The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption.
1-31. (canceled)
A pharmaceutical composition which comprises an amount of a chloroquine compound effective to increase Ataxia-Telangiectasia mutated (ATM) protein kinase activity in a mammal with metabolic syndrome and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.