Antimicrobial cationic peptides and formulations thereof
AssigneeCarrus Capital Corporation
InventorsTimothy J. Krieger, Patricia J. McNicol
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Abstract
Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.
Claims1
A method for preventing an infection caused by a prokaryotic or eukaryotic organism at a target site, comprising applying to the target site a composition comprising an antimicrobial cationic peptide at a concentration ranging from about 0.01% to about 10% (w/w), a viscosity-increasing agent, and a solvent, wherein the cationic peptide is a peptide of up to 35 amino acids comprising 11B7CN (SEQ ID NO:
- 23), the viscosity-increasing agent is hydroxyethyl cellulose at a concentration of about 0.5% to about 5% (w/w), and the solvent is water and glycerin, wherein the solvent comprises glycerin at a concentration up to about 20% (w/w), and wherein the composition is a gel.
Dependencies are inferred from the claim text.