Use of thymosin alpha for the treatment of sepsis
AssigneeSciClone Pharmaceuticals, Inc.
InventorsXiangdong GUAN, Jianfeng WU, Cynthia W. Tuthill
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AssigneeSciClone Pharmaceuticals, Inc.
InventorsXiangdong GUAN, Jianfeng WU, Cynthia W. Tuthill
Estimating the term…
The present invention provides methods for preventing, treating, or reducing the severity of sepsis, severe sepsis or septic shock, including bacterial, viral, and fungal infections, and including infections of more complex etiology. The invention involves the administration of an alpha thymosin peptide regimen. In certain embodiments, the alpha thymosin peptide regimen is scheduled or timed with respect to potential, expected and/or diagnosed sepsis, severe sepsis or septic shock. In certain embodiments, the patient is immunodeficient or immunecompromised, and/or the patient is hospitalized or scheduled for hospitalization, such that the regimen of alpha thymosin peptide peptide helps to protect the patient from, or reduce the severity of, sepsis, severe sepsis or septic shock.
A method for preventing, reducing or treating sepsis in a subject, comprising, administering a regimen of alpha thymosin peptide so as to prevent, treat or reduce the severity of the sepsis, severe sepsis or septic shock.
The method of 1, wherein the sepsis, severe sepsis or septic shock involves an infectious microorganism selected from Lysteria monocytogenes, Pseudomonas sp. (e.g., P. aeruginosa), Serratia marcescens, Clostridium difficile, Staphylococcus aureus, Staphylococcus sp., Acinetobacter spp., Enterococcus sp., Enterobacter sp., E. coli, Klebsiella sp., Streptococcus (e.g., S. pneumoniae), Haemophilus influenzae and Neisseria meningitidis.
Dependencies are inferred from the claim text.