Diagnostic tests using gene expression ratios
OwnerGavin J. Gordon, Raphael Buenoinventors
Life of this patent
Estimating the term…
Abstract
The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues. These sets of genes can be used to discriminate between normal and malignant cells or tissues, and between classes of malignant cells or tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.
Claims7
-69. (canceled)
A lung cancer diagnostic system comprising
- a measurement device that measures gene expression level data of a set of two or more genes disclosed in Table 1, 4, 5, 6, or 7, wherein the set comprises at least one upregulated gene that is expressed in greater amounts in a first type of lung cell or tissue than in a second type of lung cell or tissue and at least one downregulated gene that is expressed in lesser amounts in the first type of lung cell or tissue than in the second type of lung cell or tissue,
- a data transformation device the acquires the gene expression data from the measurement device and performs data transformation to calculate a ratio of the gene expression levels of the upregulated and downregulated genes.
-123. (canceled)
Dependencies are inferred from the claim text.