Method for discovering a biomarker
AssigneeLG Electronics Inc.
InventorsHyung-Seok CHOI, Hae Seok EO, Jee Yeon HEO
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Abstract
The invention relates to a method for discovering biomarkers, comprising: matching the expression levels of genetic factors in persons, including a plurality of patients having a specific disease, for each of the persons; and comparing the expression levels of the genetic factors and genes corresponding thereto by any one or more of cluster analysis and correlation analysis to select some of the genetic factors. According to the invention, highly accurate biomarkers for a specific disease can be discovered in a simple and easy manner.
Claims20
A method for discovering biomarkers, comprising the steps of:
- matching the expression levels of genetic factors in persons, including a plurality of patients having a specific disease, for each of the persons;
- and
- comparing the expression levels of the genetic factors and genes corresponding thereto by any one or more of cluster analysis and correlation analysis to select some of the genetic factors.
A method for discovering biomarkers by mechanism analysis, the method comprising the steps of:
- classifying genes, belonging to a candidate gene group suitable for use as biomarkers of disease, as a group related to the mechanism of action of a specific disease;
- and
- comparing the expression levels of genes of the classified group in a plurality of patient groups having the specific disease and a normal person group to select genes which are expressed more highly in the patient groups.
Breast cancer-related biomarkers including genes shown in Table 1.
Dependencies are inferred from the claim text.