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US 2013/0295656 A1Published application
Anaplasma Translocated Substrate-1 (Ats-1) and Sero-detection of Anaplasma phagocytophilum
AssigneeMedical Diagnostic Laboratories, LLC
InventorsDenise P. Dimitrov, John G. Hoey
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Abstract
Disclosed is the use of isolated Ats-1 protein in Anaplasma phagocytophilum in the ELISA detection of Anaplasma pathogen. The recombinant expression of Ats-1 and its use as a kit for ELISA are also disclosed.
Claims13
An ELISA kit for the diagnosis of Anaplasma phagocytophilum infection in a human patient, comprising:
- a) an isolated recombinant anti-Anaplasma translocated substrate-1 (Ats-1) protein antigen, said isolated recombinant Ats-1 protein antigen having an amino acid sequence of SEQ ID NO:
- 2;
- and
- b) a support having a surface, said isolated recombinant Ats-1 protein antigen is immobilized onto said surface of said support, wherein
- said immobilized isolated recombinant Ats-1 protein antigen binds to an anti-Ats-1 antibody that is present in a biological sample of a human patient suspected of having an infection of Anaplasma phagocytophilium to form a complex of antigen-antibody and the formation of said antigen-antibody complex is indicative of Anaplasma phagocytophilium infection in said human patient.
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Dependencies are inferred from the claim text.