Systems and Methods for Testing Drugs and Drug Delivery Systems

A fluidic system for performing tests on a three-dimensional (3D) cellular structure, comprising:

• a bottom panel disposed beneath said top panel, said bottom panel defining;
• a reservoir open at opposite ends for flowing a fluid therethrough and sized to contain the 3D cellular structure;
• at least one side channel flanking said reservoir and coextensive with at least a portion of a length of said reservoir, said at least one side channel open at its opposite ends for flowing a fluid therethrough;
• and
• a side wall between said reservoir and a corresponding one of said at least one side channel, said side wall defining openings for fluid communication between said reservoir and said corresponding side channel, said openings sized to simulate interstitial transport to and from a lymphatic vessel of a living animal;
• a top panel disposed above said bottom panel and defining a top channel open at opposite ends for flowing a fluid therethrough, said top channel at least partially coincident with said reservoir;
• and
• a porous membrane disposed between said top channel and said reservoir at least where said channels are coincident, said porous membrane having pores sized to mimic transvascular transport through the endothelium of a blood vessel of the living animal.