US 2013/0295181 A1 · COMPOSITIONS BASED ON PROPOLIS NANOCAPSULES WHICH CAN BE USED AS CARRIERS FOR SUBSTANCES OF INTEREST, METHODS FOR PRODUCING SAME AND USE THEREOF

Abstract

A process for obtaining compositions constituted by propolis nanoparticles is disclosed. The nanoparticles are optionally associated to a substance of interest such as active ingredients, and, optionally, substances of secondary effect such as synergists and adjuvants. The process includes preparing a fraction A, which consists of propolis extract dissolved in an organic solvent, to which stabilizer and/or emulsifier may be added, and, optionally, substances of interest and/or of secondary effect; ii) preparing a fraction B, aqueous phase, constituted by: (ii.1) water; or (ii.2) an aqueous solution or dispersion, to which stabilizer and/or emulsifier may be added; (iii) dropping the fraction A onto the fraction B or vice versa; iv) homogenizing the mixture by stifling and spontaneous formation of nanoparticles with average size from 1 to 1000 nm in a dispersion; and v) optionally (v-1) removing organic solvent and/or (v-2) drying the nanodispersion.

Claims31

Dependent claims

A process for obtaining propolis nanoparticles, characterized by comprising the steps of:

i) preparing a fraction A, which consists of propolis extract dissolved in an organic solvent at a mass-volume proportion ranging from 0.001 to 40%, to which one or more stabilizers and/or emulsifiers may be added at a concentration ranging from 0.01 to 20% (m/v), as well as, optionally, one or more substances of interest and/or of secondary effect;
ii) preparing a fraction B, in aqueous phase, constituted by:
(ii.1) water;
or (ii.2) an aqueous solution or dispersion at a concentration ranging from 0.01 to 20% (m/v), to which one or more stabilizers and/or emulsifiers may be added at a concentration ranging from 0.01 to 20% (m/v);
iii) dropping the fraction A onto the fraction B or the fraction B onto the fraction A;
iv) homogenizing the mixture and spontaneous forming nanoparticles with average size ranging from 1 to 1000 nm in a dispersion, such homogenization taking place by mechanical stirring;
v) optionally, the following additional steps may be involved:
(v-1) removing the organic solvent;
and/or (v-2) drying the nanodispersion and obtaining a powdered product.

6 more elements

Dependencies are inferred from the claim text.

Compositions based on propolis nanocapsules which can be used as carriers for substances of interest, methods for producing same and use thereof

Life of this patent

Compositions based on propolis nanocapsules which can be used as carriers for substances of interest, methods for producing same and use thereof

Life of this patent

Abstract

Claims31