Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
AssigneeThe Penn State Research Foundation
InventorsMark Kester, Thomas Stover, Tao Lowe, James H. Adair, Young Shin Kim
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Abstract
A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.
Claims20
A system for delivering a therapeutic compound to an animal or human in need of such delivery, comprising a nanoscale assembly system containing a growth-arresting, pro-apoptotic, lipid-derived bioactive compound and/or a hydrophobic chemotherapeutic agent and/or gene therapy agent.
Dependencies are inferred from the claim text.