Gas-filled microvesicles for use as vaccine
AssigneeBracco Suisse SA
InventorsGilles Bioley, Blaise CH Corthesy, Philippe Bussat, Anne Lassus, Michel Schneider
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Abstract
Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
Claims21
An immunomodulating treatment method comprising administering to a patient in need thereof a pharmaceutical formulation comprising gas-filled microvesicles with a stabilizing envelope, said microvesicles comprising an antigen covalently bound to a component of said envelope.
A method of vaccinating comprising administering to patient a suspension of gas-filled microvesicles with a stabilizing envelope, said microvesicles comprising an antigen covalently bound to a component of said envelope.
A method for increasing the uptake of an antigen by a respective antigen-presenting cell, which comprises contacting said antigen with said cell wherein said antigen is covalently bound to a gas-filled microvesicle.
Dependencies are inferred from the claim text.