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AssigneesThe Texas A&M University System, Intervet Inc.
InventorsBARBARA J. WINSLOW, Mark D. Cochran, Ellen W. Collisson, In-Soo Choi, Stephen M. Hash
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The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a protein. The protein which is encoded is selected from the groups consisting of a feline CD28 protein or an immunogenic portion thereof, a feline cD80 protein or an immunogenic portion thereof, a feline CD86 protein or an immunogenic portion thereof, or a feline CTLA-4 protein or an immunogenic portion thereof. The protein is capable of being expressed when the recombinant virus is introduced into an appropriate host. The present invention also involves a recombinant virus further comprising a foreign nucleic acid encoding an immunogen derived from a pathogen. The present invention also comprises recombinant viruses which are capable of enhancing an immune response in a feline. The present invention also comprises recombinant viruses which are capable of suppressing an immune response in a feline.
1-37. (canceled)
A recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid (a) encodes a feline CTLA-4 protein or an immunogenic portion thereof and (b) is capable of being expressed when the recombinant virus is introduced into an appropriate host.
An isolated feline CTLA-4 polypeptide comprising an amino acid sequence of SEQ ID NO:
The method of 63, wherein the administering comprises intravenous, subcutaneous, intramuscular, transmuscular, topical, oral, or intraperitoneal administration.
The method of 64, wherein the administering comprises intravenous, subcutaneous, intramuscular, transmuscular, topical, oral, or intraperitoneal administration.
A vector comprising an isolated nucleic acid encoding a feline CTLA-4 receptor, wherein the nucleic acid encodes the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.