2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Carol M. Kiekhaefer
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Abstract
A method of treating islet cell transplant patients is described herein. The method comprises the steps of a) identifying an islet cell transplant patient, b) treating the patient with 2AMD or 2AMD analog and c) observing a prolonged period of normal glycemia is disclosed. A composition for treatment of islet cell transplant patient is disclosed as well, wherein the composition comprises 50-400 ng/day of 2AMD or 2AMD analog.
Claims12
A method of treating islet cell transplant patients, comprising the steps of
- a) identifying an islet cell transplant patient,
- b) treating the patient with a sufficient amount of 2AMD or 2AMD analog such that a prolonged period of normoglycemia occurs compared to a patient who has not been treated, and
- c) observing a prolonged period of normoglycemia.
A composition for treatment of islet cell transplant patient comprising 50-400 ng/day of 2AMD or 2AMD analog.
A composition for treatment of islet cell transplant patient comprising 50-400 ng/day of 2AMD or 2AMD analog and at lease one immunosuppressant.
Dependencies are inferred from the claim text.