Shear controlled release for stenotic lesions and thrombolytic therapies
AssigneePresident and Fellows of Harvard College
InventorsDonald E. Ingber, Netanel Korin, Mathumai Kanapathipillai
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Abstract
The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.
Claims31
An aggregate for therapeutic use, comprising a plurality of nanoparticles, wherein the aggregate disaggregates above a predetermined shear stress when exposed to said predetermined shear stress.
(canceled)
5-6. (canceled)
8-10. (canceled)
13-28. (canceled)
30-36. (canceled)
The aggregate of 37, wherein shear stress in the non-stenosis region is the normal physiological shear stress.
(canceled)
The aggregate of aclaim 1, wherein the nanoparticle is of a spherical cylindrical, disc, rectangular, cubical, or irregular shape.
44-50. (canceled)
53-57. (canceled)
A method for preparing micro sized aggregates, the method comprising:
- (i) obtaining a plurality of nanoparticles;
- (ii) aggregating said plurality of nanoparticle into micron sized particles;
- and (iii) optionally selecting particles of a desired size.
59-106. (canceled)
A method of treating a stenosis and/or a stenotic lesion and/or an occlusive lesion and/or an internal hemorrhage in a subject, the method comprising administering to a subject in need thereof a red blood cell, wherein the red blood cell comprises a therapeutic agent, wherein the therapeutic agent is encapsulated in the red blood cell, and wherein the therapeutic agent is released from the red blood cell above a predetermined shear stress when exposed to said predetermined shear stress.
A method of imaging a stenosis and/or a stenotic lesion and/or an occlusive lesion and/or an internal hemorrhage in a subject, the method comprising administering to a subject in need thereof a red blood cell, wherein the red blood cell comprises an imaging agent, wherein the imaging agent is encapsulated in the red blood cell, and wherein the imaging agent is released from the red blood cell above a predetermined shear stress when exposed to said predetermined shear stress.
109-137. (canceled)
A method of treating a stenosis and/or a stenotic lesion and/or an occlusive lesion and/or an internal hemorrhage in a subject, the method comprising administering to a subject in need thereof a microcapsule comprising a therapeutic agent, wherein the therapeutic agent is encapsulated in the microcapsule;
- and wherein the microcapsule breaks apart above a predetermined shear stress when exposed to said predetermined shear stress.
A method of imaging a stenosis and/or a stenotic lesion and/or an occlusive lesion and/or an internal hemorrhage in a subject, the method comprising administering to a subject in need thereof a microcapsule comprising an imaging agent, wherein the therapeutic agent is encapsulated in the microcapsule;
- and wherein the microcapsule breaks apart above a predetermined shear stress when exposed to said predetermined shear stress.
140-172. (canceled)
Dependencies are inferred from the claim text.