Preparation of polypeptides and salts thereof
AssigneeDr. Reddy's Laboratories, Inc.
InventorsRama Rao Kvs, Santhana Krishnan Sriivasan, Basanthi Devi, Sunil Kumar Gandavadi, Karthik Ramasamy, Yagna Kiran Kumar Komaravolu, Kalyan Chakravarthi Varanasi, Ramesh Bocha, Parameswara Reddy Konche, Laxmi Reddy Katta, Rajgopal Sharma, Srilakshmi Nekkalapu
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Abstract
The application relates to processes for preparing polypeptides. Also provided are processes for preparing glatiramer acetate.
Claims34
A process for preparing a polypeptide or a pharmaceutically acceptable salt thereof, comprising:
- (a) polymerizing a mixture of protected amino acids to form a protected polypeptide;
- (b) reacting the protected polypeptide with an acid;
- (c) optionally, treating the protected polypeptide obtained in step (b) with a reagent to reduce the content of molecular impurities;
- and
- (d) reacting the protected polypeptide obtained in steps (b) or (c) with a base to form a polypeptide or a pharmaceutically acceptable salt thereof.
A process for preparing glatiramer or a pharmaceutically acceptable salt thereof, comprising:
- (a) polymerizing a mixture of the protected amino acids L-tyrosine, L-alanine, L-glutamate, and L-lysine to form protected glatiramer;
- (b) reacting the protected glatiramer with an acid;
- (c) optionally, treating the protected polypeptide obtained in step (b) with a reagent to reduce the content of molecular impurities;
- and
- (d) reacting the protected polypeptide obtained in steps (b) or (c) with a base to form a polypeptide or a pharmaceutically acceptable salt thereof.
A process for preparing a polypeptide or a pharmaceutically acceptable salt thereof, comprising:
- (a) polymerizing a mixture of protected amino acids to form a protected polypeptide;
- and
- (b) reacting the protected polypeptide with an acid to form a polypeptide or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.