Therapeutic compounds

A compound of formula I′:

• wherein:
• R4 is selected from aryl, heterocycle and heteroaryl, wherein any aryl, heterocycle and heteroaryl of R4 is optionally substituted with one or more groups each independently selected from halo, (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)haloalkyl, (C3-C7)cycloalkyl, —(C1-C6)alkyl-(C3-C7)cycloalkyl, —OH, —O(C1-C6)alkyl, —SH, —S(C1-C6)alkyl, NH2, —NH(C1-C6)alkyl and —N((C1-C6)alkyl)2, wherein (C1-C6)alkyl is optionally substituted with hydroxy, —O(C1-C6)alkyl, cyano or oxo;
• A is phenyl, monocyclic heteroaryl or monocyclic heterocycle, wherein any phenyl, monocyclic heteroaryl or monocyclic heterocycle of A is optionally substituted with one or more Z1a groups, and B is aryl, heteroaryl or heterocycle, wherein any aryl, heteroaryl or heterocycle of B is optionally substituted with one or more Z1b groups;
• or A and B together form a bicyclic aryl, bicyclic heteroaryl or bicyclic heterocycle, wherein bicyclic aryl, bicyclic heteroaryl or bicyclic heterocycle is optionally substituted with one or more Z1b groups;
• each Z1a is independently selected from halo, (C1-C3)alkyl, (C2-C3)alkenyl, (C2-C3)alkynyl, (C1-C3)haloalkyl, (C3-C7)carbocycle, heterocycle, —O(C1-C3)alkyl, —O(C2-C3)alkenyl, —O(C2-C3)alkynyl, —NRaC(O)Ra, —C(O)ORb and —C(O)NRcRd, wherein any (C3-C7)carbocycle and heterocycle of Z1a is optionally substituted with one or more halogen or (C1-C6)alkyl;
• each Z1b is independently selected from halo, CN, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)haloalkyl, (C3-C7)carbocycle, heteroaryl, heterocycle, aryl(C1-C6)alkyl-, —OH, —O(C1-C6)alkyl, —O(C2-C6)alkenyl, —O(C2-C6)alkynyl, —NRcRd, —NRaC(O)Ra, —C(O)ORb and —C(O)NRcRd, wherein any (C3-C7)carbocycle and heterocycle of Z1b is optionally substituted with one or more halogen or (C1-C6)alkyl;
• and
• Ra, Rb, Rc and Rd are each independently H or (C1-C6)alkyl;
• or a salt thereof.