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US 2013/0281392 A1Published application
Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof
AssigneeMerial Limited
InventorCharles Q. Meng
Life of this patent
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Abstract
The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
Claims53
A compound of the formula:
- wherein:
- R1 is (C1-C6)-alkyl, (C2-C5)-alkenyl, or (C2-C5)-alkynyl, each independently unsubstituted or substituted with two or more halogens;
- R2 is H or halogen;
- R3 is halogen, (C1-C6)-alkyl, (C2-C5)-alkenyl, or (C2-C5)-alkynyl, (C1-C6)-alkoxy, thienyl, furanyl, biphenyl, naphthyl, aryl, aryl ether, sulfonylaryl, sulfoxyaryl, thioaryl, (C3-C6)-cycloalkyl, or tetralin ether;
- wherein the last seven substituents may be unsubstituted or substituted with one or more of halogen, (C1-C3)-haloalkyl, (C1-C3)-haloalkoxy or carboxyl;
- R4 is H or halogen;
- R5 is H or halogen.
4 more elements
A compound of the formula:
- wherein:
- R6 is H;
- R7 is (C1-C6)-alkyl, (C2-C5)-alkenyl, or (C2-C5)-alkynyl, (C1-C6)-alkoxy, tetralin ether, bromophenoxy, phenoxy, sulfonylaryl, sulfoxyaryl, thioaryl, or (C3-C6)-cycloalkyl;
- wherein the last four substituents may be unsubstituted or substituted with one or more of halogen or (C1-C3)-alkyl;
- and
- wherein phenoxy is substituted with one or more of (C1-C3)-alkyl or trifluoromethoxy;
- R8 is H or halogen;
- R9 is H.
5 more elements
A compound of the formula:
- wherein:
- R10 is H;
- R11 is (C1-C6)-alkyl, (C2-C5)-alkenyl, or (C2-C5)-alkynyl, (C1-C6)-alkoxy, tetralin ether, aryl, aryl ether, sulfonylaryl, sulfoxyaryl, thioaryl, (C3-C6)-cycloalkyl, or;
- wherein the last six substituents may be unsubstituted or substituted with one or more of (C1-C6)-alkyl, halogen, (C1-C3)-haloalkyl, or (C1-C3)-haloalkoxy;
- R12 is H or halogen;
- R13 is H.
3 more elements
Dependencies are inferred from the claim text.