Methods for Detecting Symmetrical Dimethylarginine
AssigneeIDEXX Laboratories, Inc.
InventorsMurthy V.S.N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
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Abstract
Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
Claims18
An antibody specific for free Symmetrical Dimethyl Arginine (SDMA).
An antibody specific for a compound having the following formula:
The method of claim 17 wherein the antibody does not substantially bind to asymmetrical dimethylarginine (ADMA), L-arginine, and N-methylarginine.
Dependencies are inferred from the claim text.