Compositions and methods for detection of candida species
AssigneeT2 Biosystems, Inc.
InventorLori Anne NEELY
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Abstract
The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.
Claims60
A nucleic acid probe comprising the sequence of SEQ ID NO:
- 1.
A nucleic acid probe comprising the sequence of SEQ ID NO:
- 2.
A nucleic acid probe comprising the sequence of SEQ ID NO:
- 3.
A nucleic acid probe comprising the sequence of SEQ ID NO:
- 4.
A nucleic acid probe comprising the sequence of SEQ ID NO:
- 5.
A method for detecting at least one Candida species in a biological sample, said method comprising:
- a) contacting said sample with at least one nucleic acid probe having a sequence selected from any one of SEQ ID NOs:
- 1 to 5 under conditions which allow the at least one probe to hybridize to a nucleic acid molecule of said Candida species;
- and
- b) detecting hybridization between said at least one probe and said nucleic acid molecule, thereby detecting said at least one Candida species.
A kit comprising at least one nucleic acid probe having a sequence selected from any of SEQ ID NOs:
- 1 to 5.
Dependencies are inferred from the claim text.