Recombinant mycobacterium as vaccine for use in humans
AssigneeVakzine Projekt Management GmbH
InventorLeander Grode
Life of this patent
Estimating the term…
Abstract
The invention relates to a recombinant vaccine providing protective immunity especially against tuberculosis in human subjects.
Claims15
Vaccine for use in humans comprising as an active ingredient a recombinant Mycobacterium which is urease-deficient and which comprises a recombinant nucleic acid molecule encoding a fusion polypeptide comprising (a) a Mycobacterium antigen or an immunogenic fragment thereof, and (b) a phagolysomal escape domain.
A method for vaccinating a human subject, comprising administering a pharmaceutically effective dose of a recombinant Mycobacterium which is urease-deficient and which comprises a recombinant nucleic acid molecule encoding a fusion polypeptide comprising (a) a Mycobacterium antigen or an immunogenic fragment thereof, and (b) a phagolysomal escape domain.
Dependencies are inferred from the claim text.