# US 2013/0280184 A1 · Oral Compositions and Method for Producing Thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2013/0280184 A1 - Document ID: US20130280184A1 - Status: Published application - Kind: A1 - Application number: 13/993,722 - Filed: 2010-12-13 - Published: 2013-10-24 - Earliest claimed: 2010-12-13 - Assignees: Colgate-Palmolive Company - Inventors: Ben Gu; Mahmoud Hassan - Web page: https://patentgrep.com/patent/US20130280184A1 ## CPC - A61K 8/044: {Suspensions} - A61K 8/0216: {Solid or semisolid forms} - A61K 8/731: {Cellulose; Quaternized cellulose derivatives} - A61K 8/922: {of vegetable origin} - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Methods of preparing a dentifrice comprising polymer matrix film with a low solubility flavorant therein are disclosed. The methods comprise combining a polymer matrix film that are free of a low solubility flavorant with a dentifrice base comprising a low solubility flavorant and maintaining the combined polymer matrix film with the dentifrice base comprising low solubility flavorant for an amount of time sufficient for an amount of a low solubility flavorant to transfer from the dentifrice base comprising low solubility flavorant to the polymer matrix film Products comprising low solubility flavorant-free polymer matrix film in a dentifrice base comprising low solubility flavorant are also disclosed. ## Claims ### Claim 1 A method of preparing a dentifrice comprising polymer matrix film with low solubility flavorant therein comprising the steps of: a) forming a polymer matrix film in the substantial absence of low solubility flavorant, wherein said polymer matrix comprises a water soluble polymer; b) forming a dentifrice base comprising a low solubility flavorant; c) combining the polymer matrix film with the dentifrice base; and d) maintaining the combined polymer matrix film and dentifrice base for an amount of time suitable for an effective amount of low solubility flavorant to transfer from said dentifrice base to said polymer matrix film. ### Claim 2 (depends on 1) The method of claim 1 wherein the low solubility flavorant is selected from the group consisting of: menthol, spearmint oil, cinnamon oil, peppermint oil, clove oil, bay oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, and oil of bitter almonds. ### Claim 3 (depends on 1) The method of claim 1 wherein the polymer matrix film comprises cellulose polymers. ### Claim 4 (depends on 3) The method of claim 3 wherein said cellulose polymers comprise hydroxypropyl methyl cellulose. ### Claim 5 (depends on 1) The method of claim lany of claims 1 wherein the polymer matrix film comprises zinc oxide. ### Claim 6 (depends on 1) The method of claim 1 wherein the polymer matrix film further comprises one or more additional components selected from the group consisting of: diols, surfactants, starches, colorants, dyes, sweeteners, whitening agents, breath freshening agents, abrasives, cationic prophylactic and therapeutic agents, fluoride ion sources, stannous ion sources, tartar control agents, antimicrobial agents, antioxidants, saliva stimulating agents, antiplaque agents, anti-inflammatory agents, H2 antagonists, desensitizing agents, nutrients, and proteins. ### Claim 7 (depends on 1) The method of claim 1 wherein the dentifrice base further comprises one or more additional components selected from the group consisting of: diols, surfactants, starches, colorants, dyes, sweeteners, whitening agents, breath freshening agents, abrasives, cationic prophylactic and therapeutic agents, fluoride ion sources, stannous ion sources, tartar control agents, antimicrobial agents, antioxidants, saliva stimulating agents, antiplaque agents, anti-inflammatory agents, H2 antagonists, desensitizing agents, nutrients, and proteins. ### Claim 8 (depends on 1) The method of claim 1 further comprising the steps of: forming a low solubility flavorant free polymer matrix film by forming a slurry comprising one or more polymers and free of a low solubility flavorant, dispensing the slurry on a surface wherein the slurry forms a layer of slurry on the surface, and drying the layer of slurry to produce the low solubility flavorant free polymer matrix film. ### Claim 9 (depends on 8) The method of claim 8 further comprising the step of after drying the slurry layer to form the low solubility flavorant free polymer matrix film, cutting or punching the low solubility flavorant free polymer matrix film to form film flakes or strips of low solubility flavorant free polymer matrix film prior to combining the film with the dentifrice base. ### Claim 10 (depends on 1) The method of claim 1 wherein the polymer matrix film that is formed comprises Methocel E5, Methocel E50, ZnO Powder and Tween 80. ### Claim 11 (depends on 1) The method of claim 1 wherein polymer matrix film is formed in the substantial absence of alcohol. ### Claim 12 (depends on 1) The method of claim 1 wherein the dentifrice base that is formed comprises: Polyethylene Glycol 600, CMC 50T , Sodium Saccharin, Sodium Fluoride, Sorbitol, Purified Water, D&C Red No. 30, Silica Zeodent 114, Silica Zeodent 165, Cocaamidopropyl Betaine, Sodium Lauryl Sulfate and Menthol. ### Claim 13 (depends on 1) The method of claim 1 wherein the combined polymer matrix film and dentifrice base comprises about 0.2% menthol. ### Claim 14 (depends on 1) The method of claim 1 wherein the combined polymer matrix film and dentifrice base comprises about 1% polymer matrix film. ### Claim 15 A dentifrice product comprising with low solubility flavorant-free polymer matrix film in a dentifrice base comprising low solubility flavorant produced by the process comprising the steps of: a) forming a low solubility flavorant-free polymer matrix film in the substantial absence low solubility flavorant; b) forming a dentifrice base comprising a low solubility flavorant; and c) combining the polymer matrix film with the dentifrice base. ### Claim 16 (depends on 15) The dentifrice product of claim 15 produced by the process further comprising the steps of: forming a low solubility flavorant free polymer matrix film by forming a slurry comprising a water soluble polymer free of a low solubility flavorant, dispensing the slurry on a surface wherein the slurry forms a layer of slurry on the surface, and drying the layer of slurry to produce the low solubility flavorant free polymer matrix film. ### Claim 17 (depends on 15) The dentifrice product of claim 15 wherein the low solubility flavorant is selected from the group consisting of: menthol, spearmint oil, cinnamon oil, peppermint oil, clove oil, bay oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, and oil of bitter almonds. ### Claim 18 (depends on 15) The dentifrice product of claim 15 wherein the polymer matrix film comprises a water soluble polymer. ### Claim 19 (depends on 18) The dentifrice product of claim 18 wherein said polymer comprises hydroxypropyl methyl cellulose.