Subconjuctival implant for posterior segment drug delivery

A therapeutic device to deliver a therapeutic agent to an eye having a sclera, a conjunctiva over the sclera and a vitreous humor, the device comprising:

• a container having a reservoir chamber sized for placement between the conjunctiva and sclera, the reservoir chamber having a convex upper surface configured for placement against the conjunctiva, a concave lower surface configured for placement against the sclera, and a substantially constant volume between the upper and lower surfaces;
• a penetrable barrier disposed on the convex upper surface of the reservoir chamber for injecting an amount of a formulation of therapeutic agent into the reservoir chamber through the penetrable barrier;
• an elongate structure in fluid communication with the reservoir chamber through an opening in the concave lower surface, the elongate structure sized to extend through the sclera into the vitreous humor;
• and
• a porous structure positioned within the elongate structure to release the therapeutic amounts for the extended time,
• wherein the device is configured to release the therapeutic agent into the vitreous humor at therapeutic amounts for an extended time.