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US 2013/0274476 A1Published application
Conformationally restricted urea inhibitors of soluble epoxide hydrolase
AssigneeThe Regents of the University of California
InventorsBruce D. Hammock, Paul D. Jones, Christophe Morisseau, Huazhang Huang, Hsing-Ju Tsai, Richard Gless, JR.
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Abstract
Inhibitors of the soluble epoxide exemplary hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
Claims8
-20. (canceled)
A compound having the formula:
- wherein R1 is phenyl, optionally substituted with from 1 to 2 substituents each independently selected from the group consisting of halo, haloC1-C8alkyl, and haloC1-C8alkoxy;
- L is —CO—;
- R4 is selected from the group consisting of C1-C8alkyl, haloC1-C8alkyl and C3-C12cycloalkyl;
- the subscript n is 0;
- or a pharmaceutically acceptable salt thereof;
- with the proviso that R1 is not 4-fluorophenyl.
3 more elements
Dependencies are inferred from the claim text.